Controlling brain cell activity to reduce seizures and improve memory in epilepsy
Closed-loop Control of Interneuron Spike Timing in Epilepsy
['FUNDING_R01'] · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · NIH-11039954
This study is looking at how adjusting the timing of certain brain cells might help reduce seizures and improve memory in people with epilepsy, using a special technique in lab animals to see how these changes can make a difference.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11039954 on ClinicalTrials.gov |
What this research studies
This research investigates how controlling the timing of specific brain cells, called interneurons, can affect seizures and memory problems in epilepsy. Using a novel technique called optogenetics, researchers will manipulate the activity of these cells in rodent models of temporal lobe epilepsy. By observing how changes in interneuron timing influence seizure frequency and cognitive function, the study aims to uncover the relationship between brain activity and epilepsy symptoms. This approach could lead to new therapeutic strategies for managing epilepsy and its cognitive effects.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with temporal lobe epilepsy who experience frequent seizures and cognitive impairments.
Not a fit: Patients with epilepsy types other than temporal lobe epilepsy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for epilepsy that reduce seizures and enhance memory function.
How similar studies have performed: While the use of optogenetics in epilepsy research is a growing field, this specific approach to controlling interneuron timing is novel and has not been extensively tested.
Where this research is happening
NEW YORK, UNITED STATES
- ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SHUMAN, TRISTAN — ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
- Study coordinator: SHUMAN, TRISTAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.