Controlling blood clot digestion using advanced enzyme techniques
Official title: Modulating Fibrinolysis Dynamics by Leveraging Multivalent Avidity to Control Enzyme Activity
Funded at Indiana University Indianapolis · NIH-10881877 · Data updated 2026-11-12
This study is exploring a new way to treat blood clots, like those in the lungs or legs, by using special enzymes that can break down the clots more safely, so patients who can't use current treatments because of bleeding risks might finally have a better option.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project start | July 15, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $463,113 |
| NIH project number | 5R01HL167877-02 |
| Project ID | NIH-10881877 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with venous thromboembolism, such as pulmonary embolism or deep vein thrombosis, who are at risk of complications from current treatments.
✕Less likely to help
Patients who do not have blood clotting issues or those who are not at risk for venous thromboembolism may not benefit from this research.
What this research studies
This research investigates a new approach to improve the treatment of blood clots, specifically targeting conditions like pulmonary embolism and deep vein thrombosis. It aims to enhance the effectiveness of clot-digesting enzymes while minimizing the risk of bleeding complications that currently limit treatment options for many patients. By leveraging a novel delivery strategy that controls enzyme activity, the research seeks to provide a safer and more effective method for dissolving harmful blood clots. Patients may benefit from this innovative approach, especially those who are currently ineligible for existing therapies due to safety concerns.
Why it matters
Potential benefit: If successful, this research could lead to safer and more effective treatments for patients suffering from life-threatening blood clots.
How similar studies have gone: While the approach of using multivalent enzymatic control is innovative, similar strategies in enhancing fibrinolysis have shown promise in preliminary studies, indicating potential for success.
Where this research is happening
-
Indiana University Indianapolis
Indianapolis, United States Active
Researchers
- Principal investigator: Alves, Nathan J — Indiana University Indianapolis
- Study coordinator: Alves, Nathan J
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.