Continuous registry support for islet transplants to help people with brittle type 1 diabetes
Official title: Continuation of The Collaborative Islet Transplantation Registry (CITR)
Funded at The Emmes Company, LLC · NIH-11365197 · Data updated 2026-11-12
A national registry study will track how well islet transplantation and related therapies work and stay safe in people with brittle diabetes due to type 1 diabetes.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | The Emmes Company, LLC NIH-funded |
| Lab location | 1 site (Rockville, United States) |
| Project start | September 15, 2022 |
| Project end | June 30, 2027 |
| Funding year | 2026 |
| Award (this year) | $633,968 |
| NIH project number | 5U01DK133709-05 |
| Project ID | NIH-11365197 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with brittle type 1 diabetes who have undergone allogeneic or autologous islet transplantation or are candidates for beta cell replacement therapies.
✕Less likely to help
Non-diabetic individuals or patients not considering islet transplantation or beta cell replacement would not directly benefit.
What this research studies
This project maintains and analyzes a large registry of both donor-derived (allogeneic) and patient-derived (autologous) islet transplants and other beta cell replacement therapies. Researchers will collect and harmonize data on transplant outcomes, safety, and long-term effectiveness to understand who benefits most and under what conditions. The work is performed by a Data and Statistical Coordinating Center to support the CITR investigators and ensure high-quality, comparable information across sites. The registry helps clinicians and patients make informed decisions about using islet transplantation to reduce severe glycemic episodes and improve glucose control. Participation involves data contributed from transplant centers and patient records, with attention to privacy and safety.
Why it matters
Potential benefit: If successful, the registry could improve knowledge about who benefits from islet transplantation and guide better patient selection and post-transplant care.
How similar studies have gone: Registry-based efforts in transplant medicine have improved understanding of long-term outcomes and safety in multiple settings, though CITR-specific results remain essential.
Where this research is happening
-
The Emmes Company, LLC
Rockville, United States Active
Researchers
- Principal investigator: Payne, Elizabeth Holly — The Emmes Company, LLC
- Study coordinator: Payne, Elizabeth Holly
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.