Continued follow-up and a new case-control group in TEDDY tracking environmental links to type 1 diabetes in children
Limited Competition: Continued Follow-up of Subjects and Initiation of a Second Case-control Cohort in The Environmental Determinants of Diabetes in The Young Study (TEDDY)
This project continues tracking children in the TEDDY program and adds a matched case-control group to learn how early life environment and immune changes relate to type 1 diabetes risk.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of South Florida NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project ID | NIH-11388689 on NIH RePORTER |
What this research studies
If your child is part of TEDDY, this work keeps them in regular follow-up and asks for continued samples and health information. The Data Coordinating Center at the University of South Florida will collect, secure, and analyze data from TEDDY clinical sites and oversee data quality and protocol adherence. They will also start a second nested case-control cohort to compare children who develop early signs like autoantibodies with matched controls to search for environmental links. Study staff will protect confidentiality, monitor sites, provide statistical support, and share study-wide communications and materials.
Who could benefit from this research
Good fit: Ideal participants are children already enrolled in TEDDY—typically those identified at higher genetic risk for type 1 diabetes—and their families who can continue providing follow-up visits and samples.
Not a fit: Adults, people without a child in the TEDDY cohort, or families who are unable or unwilling to continue follow-up and sample collection are unlikely to receive direct benefits from this project.
Why it matters
Potential benefit: Results could point to environmental triggers or earlier markers of type 1 diabetes, helping guide prevention or earlier treatment strategies for at-risk children.
How similar studies have performed: TEDDY and other long-term cohort studies have successfully linked early autoantibodies to later type 1 diabetes, but finding clear environmental causes is still a work in progress, making this nested case-control approach a logical next step.
Where this research is happening
Tampa, United States
- University of South Florida — Tampa, United States (Active)
Researchers
- Principal investigator: Krischer, Jeffrey P — University of South Florida
- Study coordinator: Krischer, Jeffrey P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.