Continued follow-up and a new case-control group for TEDDY to track causes of type 1 diabetes in children
Limited Competition: Continued Follow-up of Subjects and Initiation of a Second Case-control Cohort in The Environmental Determinants of Diabetes in The Young Study (TEDDY)
This project keeps following children in the TEDDY program and adds a matched case-control group to help find environmental factors linked to early-onset type 1 diabetes.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of South Florida NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project ID | NIH-11388396 on NIH RePORTER |
What this research studies
You and your child would continue regular TEDDY follow-up visits where health information, blood samples, and exposure details are collected over time. The University of South Florida Data Coordinating Center will manage, secure, and analyze data from all TEDDY clinical sites and monitor data quality. The project adds a second nested case-control cohort to compare children who develop autoantibodies or diabetes with matched children who do not. Study materials, results, and communications will be shared with clinics and families through coordinated channels and the study website.
Who could benefit from this research
Good fit: Ideal participants are children already enrolled in TEDDY or families with young children at increased genetic risk for type 1 diabetes, especially those attending a TEDDY clinical center.
Not a fit: Adults without type 1 diabetes, people with type 2 diabetes, or children with no genetic risk for type 1 diabetes are unlikely to benefit directly from this project.
Why it matters
Potential benefit: If successful, this work could help identify triggers of type 1 diabetes and improve early detection or prevention strategies for children at risk.
How similar studies have performed: Earlier TEDDY phases and other long-term cohorts have successfully linked some environmental exposures to early autoimmunity, so this continues and expands proven cohort methods.
Where this research is happening
Tampa, United States
- University of South Florida — Tampa, United States (Active)
Researchers
- Principal investigator: Krischer, Jeffrey P — University of South Florida
- Study coordinator: Krischer, Jeffrey P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.