Connecting Latinos en Pareja (CLP): HIV prevention support for Latino male couples

Rise & Thrive: Community-Engagement Intervention to Address Chronic Stress and Prevent Depression in Adolescents and Young Adults

NIH-funded research Lurie Children's Hospital of Chicago · NIH-11252881

This program offers a four-session, culturally tailored combination of relationship skills and biomedical prevention (PrEP and ART) for Latino male couples.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionLurie Children's Hospital of Chicago NIH-funded
Lab location1 site (Chicago, United States)
Project IDNIH-11252881 on NIH RePORTER

What this research studies

You would be invited to join a randomized trial of Connecting Latinos en Pareja (CLP), a four-session program delivered with culturally and linguistically appropriate materials for Latino male couples. Sessions combine psychoeducational relationship skills with clear information about biomedical prevention options like PrEP and HIV treatment, and some parts can be delivered remotely. The project uses biological measures of medication adherence and an innovative algorithm to measure HIV protection beyond condom use. Participation includes routine follow-up and adherence monitoring to see how the program affects prevention and care outcomes.

Who could benefit from this research

Good fit: Ideal participants are Latino men in committed partnerships (including seroconcordant and serodiscordant couples) who are sexually active and interested in HIV prevention or care options.

Not a fit: Single people, couples outside the Latino community, or those not interested in biomedical prevention (PrEP/ART) or relationship-focused interventions may not benefit from this program.

Why it matters

Potential benefit: If successful, this program could help Latino male couples reduce HIV risk, improve medication adherence, and strengthen relationship-based prevention strategies.

How similar studies have performed: A prior pilot randomized trial showed high feasibility, acceptability, and promising changes in key outcomes, but a larger RCT is needed to confirm effectiveness.

Where this research is happening

Chicago, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions Acquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome Virus
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.