Connecting genetic variants to their functions in heart disease
Official title: Integrative genomic and functional genomic studies to connect variant to function for CAD GWAS loci
Funded at Columbia University Health Sciences · NIH-11049082 · Data updated 2026-11-12
This study is looking at how our genes might influence heart disease, specifically atherosclerotic coronary artery disease, to help find new treatments that could be personalized for patients like you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | April 1, 2023 |
| Project end | March 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $693,202 |
| NIH project number | 5R01HL168174-03 |
| Project ID | NIH-11049082 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with a genetic predisposition to atherosclerotic coronary artery disease.
✕Less likely to help
Patients without a genetic component to their coronary artery disease may not benefit from this research.
What this research studies
This research investigates the genetic factors contributing to atherosclerotic coronary artery disease (CAD), which is a leading cause of death worldwide. By analyzing genetic data from over 1300 subjects, the study aims to identify specific genetic variants and their roles in CAD across different tissue types. The approach combines advanced computational methods with existing data to uncover novel mechanisms and potential therapeutic targets for CAD. Patients may benefit from insights that could lead to new treatments tailored to their genetic profiles.
Why it matters
Potential benefit: If successful, this research could lead to the development of targeted therapies that improve treatment outcomes for patients with coronary artery disease.
How similar studies have gone: Previous research has shown success in linking genetic variants to disease mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Columbia University Health Sciences
New York, United States Active
Researchers
- Principal investigator: Zhang, Hanrui — Columbia University Health Sciences
- Study coordinator: Zhang, Hanrui
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.