Connecting diseases to model organism resources for better diagnosis and treatment
Official title: The Monarch Initiative: Linking Diseases to Model Organism Resources
Funded at Univ of North Carolina Chapel Hill · NIH-11134216 · Data updated 2026-11-12
This study is all about using different types of health information to better understand genetic diseases, helping doctors find the right genes linked to these conditions and improve treatments for patients with rare diseases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $1,315,692 |
| NIH project number | 7R24OD011883-13 |
| Project ID | NIH-11134216 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with rare genetic disorders or those seeking a better understanding of their genetic conditions.
✕Less likely to help
Patients with common diseases that are well understood and do not have a genetic basis may not receive benefit from this research.
What this research studies
This research focuses on improving the understanding of genetic diseases by integrating various data sources into a comprehensive collection of genotype-phenotype information. It utilizes a Knowledge Graph to link clinical and biomedical data across different organisms, which helps researchers and clinicians identify disease genes and optimize treatments. By enhancing tools and algorithms, the project aims to support rare disease diagnosis and gene-to-disease discovery, ultimately benefiting patients through improved diagnostic capabilities.
Why it matters
Potential benefit: If successful, this research could lead to more accurate diagnoses and targeted treatments for patients with genetic diseases.
How similar studies have gone: Previous phases of the Monarch Initiative have demonstrated success in using model organism data for rare disease diagnosis, indicating a promising approach.
Where this research is happening
-
Univ of North Carolina Chapel Hill
Chapel Hill, United States Active
Researchers
- Principal investigator: Haendel, Melissa a — Univ of North Carolina Chapel Hill
- Study coordinator: Haendel, Melissa a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.