Conditional gene resources and genome editing tools for zebrafish health and disease
Official title: Conditional genetics and precision genome editing resources for Zebrafish
Funded at Iowa State University · NIH-11378548 · Data updated 2026-11-12
A project to create advanced, tissue-specific gene tools in zebrafish to better model human diseases and developmental processes.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Iowa State University NIH-funded |
| Lab location | 1 site (Ames, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $982,237 |
| NIH project number | 5R24OD036201-03 |
| Project ID | NIH-11378548 on NIH RePORTER |
Who could benefit from this research
✓Could help
Not applicable to direct patient enrollment; outcomes will inform future disease modeling and translational research.
✕Less likely to help
No direct patient participation or immediate clinical benefit in this phase.
What this research studies
This grant aims to develop conditional gene resources and improved genome editing methods in zebrafish, a key model for studying human health. By enabling tissue- and time-specific control of gene function, the work could help researchers model diseases and track developmental changes more precisely. The effort will build on existing zebrafish genetics and embryo manipulation methods to expand how scientists modify gene expression and insert DNA sequences. The project involves collaboration across NIH-supported zebrafish efforts to standardize tools and make them widely usable. Outcomes may include new alleles, improved delivery techniques, and better integration of genetic changes in adult and embryonic stages.
Why it matters
Potential benefit: If successful, patients could benefit from faster translation of basic findings into disease models and potential future therapies.
How similar studies have gone: Previous zebrafish genetics projects show that tissue-specific tools can significantly advance disease modeling, with growing adoption of inducible systems.
Where this research is happening
-
Iowa State University
Ames, United States Active
Researchers
- Principal investigator: Mcgrail, Maura a. — Iowa State University
- Study coordinator: Mcgrail, Maura a.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.