Computer tools to track and analyze microbes over time
Novel Computational Methods for Microbiome Data Analysis in Longitudinal Study
['FUNDING_R01'] · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · NIH-11261730
This project builds computer tools to track how the microbiome changes over time to help people with cancer and other health conditions.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NEW YORK UNIVERSITY SCHOOL OF MEDICINE (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11261730 on ClinicalTrials.gov |
What this research studies
Researchers will create two sets of analytic tools using longitudinal microbiome sequencing data gathered through collaborations at NYU Langone. The first set will dig into raw metagenomic reads to detect closely related microbial strains, call genetic variants, and measure how strain proportions change over time. The second set will treat the microbiome as a complex ecosystem and build models that link community structure and its changes to individual patient traits. Together these computational pipelines will be applied to existing and partner-collected longitudinal datasets to better understand microbe evolution and connections to disease.
Who could benefit from this research
Good fit: Ideal candidates are people with cancer, inflammatory bowel disease, diabetes, or obesity who have provided or could provide repeated microbiome samples over time.
Not a fit: People without longitudinal microbiome samples or whose condition is unlikely to be related to microbiome changes may not receive direct benefit from this work.
Why it matters
Potential benefit: If successful, these tools could enable more precise microbiome-based diagnostics or monitoring that help guide care for cancer and other diseases.
How similar studies have performed: Previous studies have linked microbiome patterns to health outcomes, but strain-level, longitudinal computational methods are relatively new and still being validated.
Where this research is happening
NEW YORK, UNITED STATES
- NEW YORK UNIVERSITY SCHOOL OF MEDICINE — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LI, HUILIN — NEW YORK UNIVERSITY SCHOOL OF MEDICINE
- Study coordinator: LI, HUILIN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers