Computer models of how viruses interact with human cells
CORE 3 : Modeling Core
['FUNDING_OTHER'] · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · NIH-11088229
Using 3D protein maps and computer models to show how viruses like the one that causes COVID-19 attach to and change human cells to help people with infectious diseases.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN FRANCISCO (nih funded) |
| Locations | 1 site (SAN FRANCISCO, UNITED STATES) |
| Trial ID | NIH-11088229 on ClinicalTrials.gov |
What this research studies
This project builds detailed 3D models of virus–human protein complexes by combining data from cryo-electron microscopy, proteomics, and CRISPR genetic studies. It creates hierarchical, whole-cell maps that show larger compartments and organelles and identifies which subcellular parts pathogens target. The Modeling Core integrates experimental datasets and computational methods to reveal the structures and interactions that underlie infection. Initial work focuses on SARS‑CoV‑2 protein complexes and other pathogen proteins to point to possible drug or diagnostic targets.
Who could benefit from this research
Good fit: People who have had COVID‑19 or who can provide biological samples (like blood or swabs) for research are the most likely to be connected to this work.
Not a fit: Patients seeking immediate treatment options are unlikely to benefit directly because this is a computational and mapping effort rather than a clinical therapy trial.
Why it matters
Potential benefit: If successful, this could reveal new targets for drugs or diagnostics and explain how infections damage human cells.
How similar studies have performed: Similar structural and integrative mapping approaches have already identified viral protein structures and informed drug development, so this builds on established methods.
Where this research is happening
SAN FRANCISCO, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN FRANCISCO — SAN FRANCISCO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: IDEKER, TREY — UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- Study coordinator: IDEKER, TREY
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: COVID-19 infection, COVID-19 virus infection, COVID19 infection