Computer models of how RNA viruses infect human cells
In silico modeling of subcellular infection by diverse families of RNA virus
This project builds computer models to show how RNA viruses like dengue and coxsackievirus take over human cells so researchers can find weak points to target for treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project ID | NIH-11321296 on NIH RePORTER |
What this research studies
The team will create and compare two kinds of computer-based maps of viral infection: broad "generic" models that apply across many RNA viruses and detailed models specific to virus families. They will focus on dengue virus and coxsackievirus B3, using lab measurements and published data to set the model parameters. The models will simulate steps such as entry, replication, and assembly inside human cells to see which parts are most vulnerable. If the approach works, it could provide ready-made templates to study new RNA viruses during outbreaks.
Who could benefit from this research
Good fit: People affected by or at risk for RNA virus infections such as dengue or coxsackievirus might be most relevant to this work and to any future related clinical studies.
Not a fit: Patients with conditions unrelated to RNA viruses are unlikely to see direct benefit from this modeling-focused work.
Why it matters
Potential benefit: If successful, these models could speed up discovery of viral weak points and guide development of new antivirals or rapid outbreak responses.
How similar studies have performed: A small number of virus-specific computational models have provided useful insights, but applying a scalable generic approach across many RNA virus families is a newer and less-tested idea.
Where this research is happening
Charlottesville, United States
- University of Virginia — Charlottesville, United States (Active)
Researchers
- Principal investigator: Janes, Kevin a — University of Virginia
- Study coordinator: Janes, Kevin a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.