Computer models of Candida infections and gut microbes
Mathematical Modeling Core
['FUNDING_P01'] · SLOAN-KETTERING INST CAN RESEARCH · NIH-11321550
Using computer models and lab data to understand how Candida yeasts, gut bacteria, and the immune system affect the risk of gut colonization and bloodstream (candidemia) infections for patients.
Quick facts
| Phase | ['FUNDING_P01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | SLOAN-KETTERING INST CAN RESEARCH (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11321550 on ClinicalTrials.gov |
What this research studies
This project builds detailed computer models that simulate how different Candida strains process nutrients and change shape. It will also model how the gut microbiome can block Candida from taking hold and how immune responses fight candidemia. The team will combine genome sequences, laboratory assays, mouse experiments, and metabolic tracing data to create and refine these models. Laboratory collaborators will test model predictions and provide new data to improve accuracy over time.
Who could benefit from this research
Good fit: People at higher risk of Candida colonization or bloodstream infection—such as hospitalized or immunocompromised patients, those on long-term antibiotics, or people with central venous catheters—are the most likely to benefit from findings.
Not a fit: Healthy people with no history or risk factors for Candida infection are unlikely to see direct benefit.
Why it matters
Potential benefit: If successful, the work could point to new ways to prevent or treat Candida colonization and bloodstream infections by identifying microbial, metabolic, or immune targets.
How similar studies have performed: Related computational and microbiome studies have revealed important microbial interactions in other infections, but applying multi-strain metabolic models specifically to Candida and candidemia is a newer approach.
Where this research is happening
NEW YORK, UNITED STATES
- SLOAN-KETTERING INST CAN RESEARCH — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: XAVIER, JOAO — SLOAN-KETTERING INST CAN RESEARCH
- Study coordinator: XAVIER, JOAO
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.