Computer-guided planning to improve Fontan circulation
A Novel computational approach to optimize Fontan and improve surgical predictability
This project uses your medical images and computer blood-flow models to design Fontan surgery plans that lower clotting risk and improve lung blood flow for people with single-ventricle heart defects.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11263673 on NIH RePORTER |
What this research studies
You would have your imaging data fed into an automated computer workflow that builds a 3D model of your circulation and simulates blood flow. The system compares different surgical geometries to predict energy loss, uneven liver (hepatic) flow to the lungs, and clotting risk. It then suggests surgical designs that balance flows and reduce thrombosis risk. The team will test the tool using prior patient images and planned surgeries to improve how predictable and effective Fontan operations are.
Who could benefit from this research
Good fit: Ideal candidates are people with single‑ventricle heart defects who have had or are planning a Fontan procedure and who can provide clinical imaging (CT/MRI) for modeling.
Not a fit: People without single‑ventricle physiology, those not undergoing Fontan-related surgery, or those unable to provide compatible imaging are unlikely to benefit directly.
Why it matters
Potential benefit: If successful, this could lead to more personalized surgical plans that reduce post‑operative complications like thrombosis and pulmonary arteriovenous malformations.
How similar studies have performed: Related computer fluid‑dynamics planning tools have shown promising results in small series, but fully automated optimization that targets thrombosis and hepatic flow balance is relatively new.
Where this research is happening
Boston, United States
- Boston Children's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Govindarajan, Vijay — Boston Children's Hospital
- Study coordinator: Govindarajan, Vijay
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.