Computer genomics support for bone marrow cancer research
Core B: Computational Genomics Core
This project uses computer tools to combine DNA, RNA, and protein data from bone marrow to map cell types and signals in people with blood cancers like acute myeloid leukemia.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11181665 on NIH RePORTER |
What this research studies
Researchers will collect genomic, transcriptomic, and proteomic data from bone marrow tissue and use advanced computational methods to map where different cell types and their activity patterns sit in the bone marrow. The Core will integrate data from three linked projects and apply spatial mapping to show how cells communicate and change during cancer development. Teams will develop and refine new algorithms and pipelines, provide computational support to lab scientists, and train staff to analyze large-scale datasets. Results will be used to chart how cell states and signaling become abnormal during AML transformation and to guide follow-up studies.
Who could benefit from this research
Good fit: Ideal candidates would be people with bone marrow cancers such as acute myeloid leukemia who can provide bone marrow or blood samples at Columbia or a participating center.
Not a fit: People without bone marrow or blood cancers or those seeking immediate treatment changes are unlikely to receive direct clinical benefit from this core research.
Why it matters
Potential benefit: If successful, this work could reveal how blood cancers form and progress and point to new targets for diagnosis or personalized treatments.
How similar studies have performed: Related spatial multi-omics studies have shown promising insights into tumor cell states and microenvironments, but these methods are still emerging and not yet routine clinical practice.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Rabadan, Raul — Columbia University Health Sciences
- Study coordinator: Rabadan, Raul
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.