Computer-based speed-of-processing training to lower dementia and MCI risk in older adults
Cognitive training to reduce incidence of cognitive impairment in older adults
Older adults will use computer-based speed-of-processing brain training or active computer games so researchers can find out whether the training lowers the chance of developing mild cognitive impairment or dementia.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of South Florida NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project ID | NIH-11064083 on NIH RePORTER |
What this research studies
You would be randomly assigned to do computerized speed-of-processing training or to play active brain-stimulating computer games as a comparison. The program is delivered over repeated sessions and participants are followed over time with regular check-ins and clinical exams. The main outcome is whether people develop a clinical diagnosis of mild cognitive impairment (MCI) or dementia during follow-up. This builds on prior trials that showed cognitive and daily function benefits and suggests the training might lower dementia risk.
Who could benefit from this research
Good fit: Ideal candidates are older adults who are currently cognitively normal, able to use a computer, and willing to join a multi-year follow-up program.
Not a fit: People who already have MCI or dementia, or who cannot participate in computer-based activities, are unlikely to benefit from this prevention-focused program.
Why it matters
Potential benefit: If successful, this could offer a low-cost, widely available way to lower the risk of developing MCI or dementia in older adults.
How similar studies have performed: Previous randomized trials, including long-term follow-up from the ACTIVE trial, showed speed-of-processing training improves thinking and was linked to a lower dementia risk (about 29% reduced risk, larger with extra training), though larger trials with clinical diagnoses have been limited.
Where this research is happening
Tampa, United States
- University of South Florida — Tampa, United States (Active)
Researchers
- Principal investigator: O'brien, Jennifer Lee — University of South Florida
- Study coordinator: O'brien, Jennifer Lee
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.