Computational modeling of cell-surface Ig domain interactions
Official title: Computational modeling of interactions between cell surface proteins with multiple domains in the immunoglobulin fold
Funded at Albert Einstein College of Medicine · NIH-11446783 · Data updated 2026-11-12
A computer-based study to understand how parts of cell-surface proteins with Ig-like domains recognize and bind to multiple partners, which influences how cells communicate.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Albert Einstein College of Medicine NIH-funded |
| Lab location | 1 site (Bronx, United States) |
| Project start | August 15, 2026 |
| Project end | July 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $361,200 |
| NIH project number | 1R01GM162824-01A1 |
| Project ID | NIH-11446783 on NIH RePORTER |
Who could benefit from this research
✓Could help
Not applicable to a specific patient group at this stage; the research is basic and computational.
✕Less likely to help
No direct patient benefit at this phase since the work is computational and foundational.
What this research studies
This project uses computer modeling to map which Ig-domain regions drive binding between cell-surface proteins. It aims to reveal how different extracellular domains contribute to binding strength and partner choice, especially when proteins have multiple Ig domains. By combining structural data with advanced simulations, the work seeks to overcome limitations of traditional lab assays in capturing transient interactions. The ultimate goal is to clarify how these interactions shape signaling and cellular communication in health and disease.
Why it matters
Potential benefit: It could lead to better understanding of immune and cellular signaling processes and inform future therapies targeting cell-surface interactions.
How similar studies have gone: Previous studies have successfully used computational modeling to predict protein interactions; this project builds on those approaches with multi-domain Ig proteins.
Where this research is happening
-
Albert Einstein College of Medicine
Bronx, United States Active
Researchers
- Principal investigator: Wu, Yinghao — Albert Einstein College of Medicine
- Study coordinator: Wu, Yinghao
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.