Comprehensive Radiotherapy and Tumor Immunity Assessment for Cervical Cancer
METEOR-Comprehensive Radiobiology Assessment TRial (METEOR-CRATR)
This project will collect tumor, blood, and imaging samples from people with locally advanced cervical cancer who are receiving pelvic radiation and cisplatin to find out how treatment changes the tumor's immune environment.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-11168908 on NIH RePORTER |
What this research studies
I may be invited to join if I have locally advanced cervical cancer and am receiving pelvic radiation with concurrent cisplatin. The team will collect tumor biopsies, blood samples, detailed radiation dose information, and imaging before, during, and after treatment. They will use single-cell and spatial genomic techniques to map cancer and immune cells inside the tumor and link those maps to clinical outcomes. The aim is to learn why some tumors come back or resist radiation so future care can be better targeted.
Who could benefit from this research
Good fit: Ideal participants are people with locally advanced cervical cancer scheduled for pelvic radiation with concurrent cisplatin who can provide biopsy and blood samples.
Not a fit: People with early-stage cervical cancer not receiving chemoradiation, those with other cancer types, or patients unable or unwilling to undergo biopsies are unlikely to receive direct benefit from this project.
Why it matters
Potential benefit: If successful, this work could help doctors predict who is more likely to relapse after chemoradiation and suggest new treatments that boost the immune response to radiation.
How similar studies have performed: Other single-cell and spatial tumor-mapping studies have revealed important immune changes, but using these methods to predict or prevent relapse after chemoradiation in cervical cancer is largely new.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Robinson, Clifford Grant — Washington University
- Study coordinator: Robinson, Clifford Grant
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.