Comparing withdrawal symptoms between vapers and cigarette smokers

A controlled evaluation of abstinence-induced withdrawal and motivation to vape/smoke among daily ENDS users vs. cigarette smokers

['FUNDING_R01'] · STATE UNIVERSITY OF NEW YORK AT BUFFALO · NIH-11081008

This study is looking at how people who vape and those who smoke regular cigarettes feel when they try to stop using nicotine, focusing on things like cravings and emotions, to help us understand what keeps them motivated to use these products.

Quick facts

Phase['FUNDING_R01']
Study typeNih_funding
SexAll
SponsorSTATE UNIVERSITY OF NEW YORK AT BUFFALO (nih funded)
Locations1 site (AMHERST, UNITED STATES)
Trial IDNIH-11081008 on ClinicalTrials.gov

What this research studies

This research investigates the withdrawal symptoms experienced by individuals who use electronic nicotine delivery systems (ENDS) compared to those who smoke traditional cigarettes. It aims to understand how these withdrawal symptoms, such as cravings and negative emotions, influence the motivation to continue using nicotine products. Participants will include daily vapers, daily smokers, and dual users, who will undergo controlled lab visits to assess their experiences after a period of abstinence. The study employs advanced methods to measure various aspects of withdrawal, providing insights into the differences between these two groups.

Who could benefit from this research

Good fit: Ideal candidates for this research are individuals aged 21 and older who are daily users of either electronic nicotine delivery systems or traditional cigarettes.

Not a fit: Patients who do not use nicotine products or are not interested in quitting smoking or vaping may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could lead to improved treatments for nicotine dependence by better understanding withdrawal symptoms.

How similar studies have performed: While there is extensive research on withdrawal from combustible cigarettes, this study represents a novel approach to understanding withdrawal from electronic nicotine delivery systems.

Where this research is happening

AMHERST, UNITED STATES

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.

View on NIH RePORTER →

Last reviewed 2026-05-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.