Comparing whole blood to blood components for trauma patients
2/2 Trauma Resuscitation with Group O Whole Blood or Products (TROOP)
This study is looking at whether using whole blood instead of separate blood components can help trauma patients who need a lot of blood transfusions recover better and stay safer, and it involves several hospitals where participants will be randomly chosen to receive one of the two treatments.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Sci Ctr Houston NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-10925333 on NIH RePORTER |
What this research studies
This research investigates the effectiveness and safety of using whole blood compared to traditional blood component therapy in trauma patients who are expected to need large volume blood transfusions. The study is a multicenter, phase III clinical trial that will involve multiple hospitals and aims to determine if whole blood can reduce mortality rates in critically injured patients. Participants will be randomly assigned to receive either whole blood or standard blood components, and their outcomes will be monitored closely over a six-hour period. The goal is to provide a more effective and potentially safer approach to trauma resuscitation.
Who could benefit from this research
Good fit: Ideal candidates for this research are trauma patients who are predicted to require large volume blood transfusions.
Not a fit: Patients who do not require blood transfusions or those with conditions that contraindicate blood transfusion may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved survival rates and better outcomes for trauma patients requiring blood transfusions.
How similar studies have performed: While there have been some observational studies on this topic, this trial represents a novel and rigorous approach to evaluating whole blood transfusion in trauma care.
Where this research is happening
Houston, United States
- University of Texas Hlth Sci Ctr Houston — Houston, United States (Active)
Researchers
- Principal investigator: Desantis, Stacia — University of Texas Hlth Sci Ctr Houston
- Study coordinator: Desantis, Stacia
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.