Comparing universal and guideline-directed genetic testing for young adults with cancer
Randomized trial of universal vs. guideline-directed germline testing among young adults with cancer
This study is looking at whether universal genetic testing can find inherited cancer risks better than the usual testing methods for young adults with cancer, helping to improve care for them and their families.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10596783 on NIH RePORTER |
What this research studies
This research investigates the effectiveness of universal genetic testing compared to guideline-directed testing in young adults diagnosed with cancer. It aims to identify inherited genetic risks that are often missed by current testing guidelines, which may not adequately account for the unique biology of cancers in individuals under 40. The study will involve a randomized controlled trial with 1,421 participants, focusing on improving genetic testing rates and integrating results into electronic medical records to enhance patient care. By addressing barriers to genetic testing for patients and their relatives, the research seeks to improve screening and risk-reduction strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are young adults under 40 who have been diagnosed with cancer.
Not a fit: Patients over the age of 40 or those without a cancer diagnosis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better identification of genetic risks in young adults with cancer, improving treatment options and outcomes.
How similar studies have performed: Previous research has shown that improved genetic testing strategies can enhance patient outcomes, indicating potential success for this approach.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Nathanson, Katherine L. — University of Pennsylvania
- Study coordinator: Nathanson, Katherine L.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.