Comparing two types of saline fluids for treating sepsis in children
Finding Appropriate Subtypes in a Trial of Balanced versus nOrmaL Saline FlUid in Sepsis
This study is looking at whether balanced fluids like lactated Ringer’s work better than normal saline for treating sepsis in kids, with the goal of helping to prevent kidney problems and improve recovery.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hosp of Philadelphia NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10892884 on NIH RePORTER |
What this research studies
This research investigates the effectiveness of balanced crystalloid solutions, like lactated Ringer’s, compared to normal saline in treating sepsis in children. Sepsis is a severe response to infection that can lead to significant health complications, and fluid therapy is a critical part of treatment. The study aims to enroll 8,800 children to determine which fluid type better prevents kidney-related complications and improves overall outcomes. By focusing on pediatric patients, the research seeks to provide tailored insights that differ from adult studies.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 0-21 who are diagnosed with sepsis and require fluid resuscitation.
Not a fit: Patients who are not diagnosed with sepsis or are outside the age range of 0-21 may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment protocols for sepsis in children, potentially reducing kidney complications and mortality rates.
How similar studies have performed: Previous adult studies have shown that balanced fluids may reduce kidney complications, suggesting potential for success in pediatric applications, although this specific approach in children is novel.
Where this research is happening
Philadelphia, United States
- Children's Hosp of Philadelphia — Philadelphia, United States (Active)
Researchers
- Principal investigator: Yehya, Nadir — Children's Hosp of Philadelphia
- Study coordinator: Yehya, Nadir
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.