Comparing two treatments that remove abnormal cervical cells to lower cancer risk in women with HIV in Mozambique
A Randomized Clinical Trial to Assess the Effectiveness of Ablative Treatments for Cervical Cancer Risk Reduction in HIV+ Women living in Mozambique
This project compares two ways of removing precancerous cervical tissue in women living with HIV in Mozambique to help prevent cervical cancer.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tx Md Anderson Can Ctr NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-11161143 on NIH RePORTER |
What this research studies
If you join, you will be screened during your routine HIV clinic visit for high-risk HPV and precancerous cervical changes. Women who are eligible will be randomly assigned to receive either gas-based cryotherapy or thermocoagulation to remove abnormal tissue. The treatments are delivered at participating clinics in Maputo and you will return for follow-up visits so the team can check if the treatment worked and if HPV or precancer returns. The trial aims to enroll thousands of women to learn which option better reduces cervical cancer risk in women living with HIV.
Who could benefit from this research
Good fit: Ideal candidates are women aged 25–49 who are living with HIV, receive care in Maputo, Mozambique, and have screening results showing high-risk HPV or precancerous cervical lesions.
Not a fit: Women who do not have HIV, who already have invasive cervical cancer, who are outside the age range, or who do not live near participating clinics are unlikely to be eligible or to benefit directly from this project.
Why it matters
Potential benefit: If successful, this work could identify the more effective, practical treatment to lower cervical cancer risk in women living with HIV in Mozambique and similar settings.
How similar studies have performed: Both cryotherapy and thermocoagulation are already used to treat precancerous cervical lesions, but large randomized comparisons specifically in women living with HIV in sub-Saharan Africa are limited.
Where this research is happening
Houston, United States
- University of Tx Md Anderson Can Ctr — Houston, United States (Active)
Researchers
- Principal investigator: Schmeler, Kathleen — University of Tx Md Anderson Can Ctr
- Study coordinator: Schmeler, Kathleen
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.