Comparing two treatment approaches for laryngopharyngeal reflux symptoms
The MVP Trial: A Randomized Controlled Trial of Mechanism Guided vs PPI Strategy for Laryngopharyngeal Reflux
This study is looking at a new way to treat laryngopharyngeal reflux (LPR) symptoms to see if it works better than the usual medication, and it's for people who want to find a more effective solution for their LPR issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-11045562 on NIH RePORTER |
What this research studies
This research investigates the effectiveness of a new treatment strategy for laryngopharyngeal reflux (LPR) symptoms compared to the standard proton pump inhibitor (PPI) therapy. It aims to identify the underlying mechanisms contributing to LPR symptoms and develop a targeted therapy that addresses these mechanisms. Patients will undergo evaluations that include novel diagnostic metrics and potentially benefit from a more tailored treatment approach. The study seeks to improve patient outcomes by providing clearer diagnoses and effective therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 21 years old who experience persistent laryngeal symptoms and have not found relief from standard PPI treatments.
Not a fit: Patients who do not have laryngopharyngeal reflux or those who have already found effective treatment for their symptoms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for patients suffering from laryngopharyngeal reflux, improving their quality of life.
How similar studies have performed: Previous research has shown that targeted therapies can be more effective than standard treatments for similar conditions, indicating potential for success in this novel approach.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Yadlapati, Rena Hiren — University of California, San Diego
- Study coordinator: Yadlapati, Rena Hiren
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.