Comparing two treatment approaches for laryngopharyngeal reflux symptoms
Official title: The MVP Trial: A Randomized Controlled Trial of Mechanism Guided vs PPI Strategy for Laryngopharyngeal Reflux
Funded at University of California, San Diego · NIH-11045562 · Data updated 2026-11-12
This study is looking at a new way to treat laryngopharyngeal reflux (LPR) symptoms to see if it works better than the usual medication, and it's for people who want to find a more effective solution for their LPR issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | September 24, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $674,854 |
| NIH project number | 1R01DK139089-01A1 |
| Project ID | NIH-11045562 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults over 21 years old who experience persistent laryngeal symptoms and have not found relief from standard PPI treatments.
✕Less likely to help
Patients who do not have laryngopharyngeal reflux or those who have already found effective treatment for their symptoms may not benefit from this research.
What this research studies
This research investigates the effectiveness of a new treatment strategy for laryngopharyngeal reflux (LPR) symptoms compared to the standard proton pump inhibitor (PPI) therapy. It aims to identify the underlying mechanisms contributing to LPR symptoms and develop a targeted therapy that addresses these mechanisms. Patients will undergo evaluations that include novel diagnostic metrics and potentially benefit from a more tailored treatment approach. The study seeks to improve patient outcomes by providing clearer diagnoses and effective therapies.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for patients suffering from laryngopharyngeal reflux, improving their quality of life.
How similar studies have gone: Previous research has shown that targeted therapies can be more effective than standard treatments for similar conditions, indicating potential for success in this novel approach.
Where this research is happening
-
University of California, San Diego
La Jolla, United States Active
Researchers
- Principal investigator: Yadlapati, Rena Hiren — University of California, San Diego
- Study coordinator: Yadlapati, Rena Hiren
Related research
Other NIH-funded projects on the same topics.
-
Cognitive behavioral therapy and trazodone for insomnia phenotypes with high blood pressure
A clinical study tests how CBT-I and the sleep drug trazodone work for adults with insomnia and high blood pressure, focusing on a specific sleep duration pattern.
-
Shorter antifungal treatment for kids with candidemia
A multi-center pediatric trial tests whether a shorter, 7 extra days of antifungal therapy after an initial 7 days is just as good as the standard 14-day approach for kids with candidemia who are improving on echinocandin therapy.
-
Short Course vs Standard Course Antifungal Therapy for Pediatric Candidemia
This study tests whether a shorter 7-day total antifungal treatment after an initial 7 days of echinocandin therapy is as effective as the usual 14-day course for children with candidemia.
-
Shorter antifungal treatment for kids with candidemia
A multi-center study tests whether kids with candidemia can finish treatment earlier after an initial week of antifungal therapy than the standard two weeks total.
-
Shorter antifungal treatment for kids with candidemia
This study tests whether children with candidemia can finish treatment after 7 days of an echinocandin if they are improving, instead of completing a full 14 days.
-
Shorter antifungal course for kids with candidemia
A multi-center study tests whether 7 extra days of antifungal therapy after an initial week of treatment can be shortened safely for children with candidemia.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.