Comparing two surgical methods for treating bone cancer in the thigh
A Planning Grant for a Multi-Center Randomized Controlled Trial Comparing Resection and Endoprosthetic Reconstruction vs. Internal Fixation for Metastatic Bone Disease of the Proximal Femur
This study is looking at two different surgical options for people with cancer that has spread to the upper part of the thigh bone, to see which one helps them move better and enjoy life more after surgery.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Maryland Baltimore NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-11059121 on NIH RePORTER |
What this research studies
This research investigates the effectiveness of two surgical approaches for patients with metastatic bone disease affecting the proximal femur, which is the upper part of the thigh bone. One method involves internal fixation, a less invasive procedure that stabilizes the bone, while the other method involves complete resection of the affected bone followed by endoprosthetic reconstruction, which is more invasive but may lead to better long-term outcomes. The study aims to gather data from multiple centers to compare these methods and determine which provides better mobility and quality of life for patients. Patients will be monitored for complications and overall recovery to assess the best treatment option.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with metastatic bone disease specifically affecting the proximal femur.
Not a fit: Patients with metastatic bone disease in locations other than the proximal femur may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved surgical outcomes and quality of life for patients with metastatic bone disease.
How similar studies have performed: Previous studies have shown promising results for similar surgical approaches, but this research aims to provide more robust evidence through a multi-center trial.
Where this research is happening
Baltimore, United States
- University of Maryland Baltimore — Baltimore, United States (Active)
Researchers
- Principal investigator: O'hara, Nathan Noel — University of Maryland Baltimore
- Study coordinator: O'hara, Nathan Noel
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.