Comparing two surgical methods for treating bone cancer in the thigh
Official title: A Planning Grant for a Multi-Center Randomized Controlled Trial Comparing Resection and Endoprosthetic Reconstruction vs. Internal Fixation for Metastatic Bone Disease of the Proximal Femur
Funded at University of Maryland Baltimore · NIH-11059121 · Data updated 2026-11-12
This study is looking at two different surgical options for people with cancer that has spread to the upper part of the thigh bone, to see which one helps them move better and enjoy life more after surgery.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Maryland Baltimore NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | April 1, 2024 |
| Project end | March 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $136,171 |
| NIH project number | 5R34AR084146-02 |
| Project ID | NIH-11059121 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with metastatic bone disease specifically affecting the proximal femur.
✕Less likely to help
Patients with metastatic bone disease in locations other than the proximal femur may not benefit from this research.
What this research studies
This research investigates the effectiveness of two surgical approaches for patients with metastatic bone disease affecting the proximal femur, which is the upper part of the thigh bone. One method involves internal fixation, a less invasive procedure that stabilizes the bone, while the other method involves complete resection of the affected bone followed by endoprosthetic reconstruction, which is more invasive but may lead to better long-term outcomes. The study aims to gather data from multiple centers to compare these methods and determine which provides better mobility and quality of life for patients. Patients will be monitored for complications and overall recovery to assess the best treatment option.
Why it matters
Potential benefit: If successful, this research could lead to improved surgical outcomes and quality of life for patients with metastatic bone disease.
How similar studies have gone: Previous studies have shown promising results for similar surgical approaches, but this research aims to provide more robust evidence through a multi-center trial.
Where this research is happening
-
University of Maryland Baltimore
Baltimore, United States Active
Researchers
- Principal investigator: O'hara, Nathan Noel — University of Maryland Baltimore
- Study coordinator: O'hara, Nathan Noel
Related research
Other NIH-funded projects on the same topics.
-
Cognitive behavioral therapy and trazodone for insomnia phenotypes with high blood pressure
A clinical study tests how CBT-I and the sleep drug trazodone work for adults with insomnia and high blood pressure, focusing on a specific sleep duration pattern.
-
Shorter antifungal treatment for kids with candidemia
A multi-center pediatric trial tests whether a shorter, 7 extra days of antifungal therapy after an initial 7 days is just as good as the standard 14-day approach for kids with candidemia who are improving on echinocandin therapy.
-
Short Course vs Standard Course Antifungal Therapy for Pediatric Candidemia
This study tests whether a shorter 7-day total antifungal treatment after an initial 7 days of echinocandin therapy is as effective as the usual 14-day course for children with candidemia.
-
Shorter antifungal treatment for kids with candidemia
A multi-center study tests whether kids with candidemia can finish treatment earlier after an initial week of antifungal therapy than the standard two weeks total.
-
Shorter antifungal treatment for kids with candidemia
This study tests whether children with candidemia can finish treatment after 7 days of an echinocandin if they are improving, instead of completing a full 14 days.
-
Shorter antifungal course for kids with candidemia
A multi-center study tests whether 7 extra days of antifungal therapy after an initial week of treatment can be shortened safely for children with candidemia.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.