Comparing two medications for treating opioid dependence in individuals leaving jail
Official title: A comparative effectiveness trial of extended release naltrexone versus extended-release buprenorphine with individuals leaving jail
Funded at Friends Research Institute, INC. · NIH-10616501 · Data updated 2026-11-12
This study is looking at how well two medications, naltrexone and buprenorphine, help people who are coming out of jail and trying to overcome opioid dependence, by seeing which one works better for staying on track and improving their lives.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Friends Research Institute, INC. NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | July 15, 2019 |
| Project end | April 30, 2026 |
| Funding year | 2023 |
| Award (this year) | $1,967,149 |
| NIH project number | 5UG1DA050077-05 |
| Project ID | NIH-10616501 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are incarcerated men and women who are struggling with opioid dependence and are preparing for re-entry into the community.
✕Less likely to help
Patients who are not opioid-dependent or those who are not transitioning from jail may not benefit from this research.
What this research studies
This research investigates the effectiveness of two medications, extended-release naltrexone and extended-release buprenorphine, in treating opioid dependence among individuals transitioning from jail to community care. Participants will be randomly assigned to receive one of the medications while incarcerated, followed by continued treatment in the community. The study aims to assess various outcomes, including adherence to medication, opioid use, and overall quality of life, to determine which treatment is more effective in reducing relapse and improving health outcomes.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options for individuals with opioid dependence, potentially reducing relapse rates and enhancing recovery outcomes.
How similar studies have gone: Previous research has shown promising results in using extended-release formulations for opioid dependence, indicating that this approach may be effective.
Where this research is happening
-
Friends Research Institute, INC.
Baltimore, United States Active
Researchers
- Principal investigator: Gordon, Michael Scott — Friends Research Institute, INC.
- Study coordinator: Gordon, Michael Scott
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.