Comparing treatments for binge eating disorder
Official title: Cognitive-Behavioral and Pharmacologic Treatment of Binge Eating Disorder
Funded at Yale University · NIH-10443560 · Data updated 2026-11-12
This study is looking at how well a medication called lisdexamfetamine and a type of therapy called cognitive behavioral therapy can help people with binge eating disorder, and it will also check if using them together works better, while exploring other medication options for those who might not respond to the first treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | August 1, 2018 |
| Project end | June 30, 2025 |
| Funding year | 2022 |
| Award (this year) | $673,596 |
| NIH project number | 5R01DK114075-05 |
| Project ID | NIH-10443560 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are individuals diagnosed with binge eating disorder, particularly those who are also obese.
✕Less likely to help
Patients who do not have binge eating disorder or those who are not obese may not benefit from this research.
What this research studies
This research investigates the effectiveness of two treatments for binge eating disorder (BED): a medication called lisdexamfetamine (LDX) and cognitive behavioral therapy (CBT). Patients will participate in a randomized controlled trial to see how well these treatments work individually and in combination. The study aims to determine not only the immediate effects of these treatments but also their long-term benefits for patients who respond positively. Additionally, it will explore alternative medication options for those who do not respond to initial treatments.
Why it matters
Potential benefit: If successful, this research could lead to more effective and sustained treatment options for patients with binge eating disorder.
How similar studies have gone: Previous research has shown promising results for both cognitive behavioral therapy and pharmacotherapy in treating eating disorders, but this specific combination approach is relatively novel.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Grilo, Carlos M — Yale University
- Study coordinator: Grilo, Carlos M
Related research
Other NIH-funded projects on the same topics.
-
Understanding Binge Eating Disorder in Older Hispanic Women
This project looks at how chronic binge eating disorder affects the health of older Hispanic women who also face challenges with food security.
-
Social media habits and binge-eating in teens
This project will see if patterns of social media use predict binge-eating behaviors in adolescents.
-
Using digital mindfulness meditation to improve therapy for binge eating disorder
This study is testing a new online program that combines mindfulness meditation with traditional therapy to help people with binge eating disorder feel better and manage their eating habits more effectively.
-
Exploring how social media use affects binge-eating disorder in adolescents
This study looks at how using social media a lot might be linked to binge-eating in teens, especially considering things like feeling sad, anxious, or being bullied online, and it hopes to offer helpful advice for teens, their parents, and doctors to prevent these eating issues.
-
Impact of binge eating disorder on older Hispanic women facing food insecurity
This study is looking at how binge eating disorder affects Hispanic women over 65 who don’t always have enough food, to better understand their health challenges and improve care for them.
-
Investigating brain changes in binge eating disorder using advanced imaging techniques
This study is looking at how binge eating disorder affects the brain by using a special imaging technique to see changes in brain connections, and it's for people who want to help improve treatments for this condition.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.