Comparing the safety of seizure prevention treatments for older adults with Alzheimer's disease
Comparative Safety of Seizure Prophylaxis within the Medicare Program
This study is looking at how safe and helpful seizure prevention medications are for older adults with Alzheimer's and related conditions, so we can better guide their treatment and keep them safe after a stroke.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11109413 on NIH RePORTER |
What this research studies
This research investigates the safety of anticonvulsant medications used for seizure prevention in Medicare beneficiaries, particularly those with Alzheimer's disease and related dementias. It aims to understand the risks and benefits of these medications, which can be life-saving but also pose serious adverse effects. By analyzing a unique dataset that combines information from registries, electronic health records, and Medicare claims, the study will develop predictive models to guide treatment decisions for patients who have experienced strokes or have dementia. The goal is to improve the management of seizure prophylaxis in this vulnerable population.
Who could benefit from this research
Good fit: Ideal candidates for this research are Medicare beneficiaries aged 65 and older who have Alzheimer's disease or related dementias and may require seizure prophylaxis.
Not a fit: Patients under the age of 65 or those without Alzheimer's disease or related dementias are unlikely to benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to safer and more effective treatment protocols for older adults at risk of seizures due to Alzheimer's disease.
How similar studies have performed: While there is limited existing research on this specific topic, the use of Medicare claims data for similar studies has shown promise in understanding treatment outcomes in older populations.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Moura, Lidia Maria Veras Rocha de — Massachusetts General Hospital
- Study coordinator: Moura, Lidia Maria Veras Rocha de
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.