Comparing the safety of non-opioid pain medications
Comparative Safety of Pain Medications
This study is looking at the safety of three common pain medications—cyclobenzaprine, duloxetine, and pregabalin—to see if they might cause heart problems, especially in people who often don’t get included in medical research. The goal is to help doctors make better choices for managing chronic pain for their patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Miami School of Medicine NIH-funded |
| Lab location | 1 site (Coral Gables, United States) |
| Project ID | NIH-10773769 on NIH RePORTER |
What this research studies
This research investigates the safety of three commonly prescribed non-opioid medications—cyclobenzaprine, duloxetine, and pregabalin—used for chronic pain management. It aims to identify potential cardiovascular risks associated with these medications, particularly in vulnerable populations often excluded from clinical trials. By utilizing pharmacoepidemiologic studies, the research will analyze data to provide critical insights into the long-term safety of these drugs, which are used by millions of patients. The findings could help clinicians make informed decisions about pain management options.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from chronic pain who are prescribed non-opioid medications.
Not a fit: Patients who do not use non-opioid medications or those with acute pain conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to safer pain management options for patients with chronic pain, reducing the risk of serious cardiovascular events.
How similar studies have performed: Previous research has indicated potential cardiovascular risks associated with similar medications, suggesting that this investigation could provide valuable insights.
Where this research is happening
Coral Gables, United States
- University of Miami School of Medicine — Coral Gables, United States (Active)
Researchers
- Principal investigator: Chung, Cecilia Pilar — University of Miami School of Medicine
- Study coordinator: Chung, Cecilia Pilar
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.