Comparing the effects of two diuretics on heart failure outcomes
Official title: The optimal loop diuretic: mechanistic insights from longitudinal changes in blood and urine proteins to explain efficacy and safety of torsemide vs furosemide after a heart failure hospitalization
Funded at Inova Health Care Services · NIH-10683741 · Data updated 2026-11-12
This study is looking at how two common water pills, torsemide and furosemide, help people with heart failure after they leave the hospital, and it aims to find out if one works better or is safer than the other for different groups of patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Inova Health Care Services NIH-funded |
| Lab location | 1 site (Fairfax, UNITED STATES) |
| Project start | September 1, 2020 |
| Project end | August 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $387,840 |
| NIH project number | 5R01HL154768-04 |
| Project ID | NIH-10683741 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients who have been hospitalized for heart failure and are prescribed diuretics.
✕Less likely to help
Patients who are not hospitalized for heart failure or those who do not require diuretic therapy may not benefit from this research.
What this research studies
This research investigates how two commonly used diuretics, torsemide and furosemide, affect patients with heart failure after hospitalization. By collecting blood and urine samples from participants at the start of the study and again after 90 days, researchers will analyze the proteins present to understand how each medication works in the body. The goal is to determine if one diuretic is more effective or safer than the other, particularly across different patient groups defined by gender, race, and heart function. This study aims to provide insights that could improve treatment decisions for heart failure patients.
Why it matters
Potential benefit: If successful, this research could lead to more personalized and effective treatment options for heart failure patients.
How similar studies have gone: Previous research has shown varying outcomes with different diuretics in heart failure, but this specific mechanistic approach is novel.
Where this research is happening
-
Inova Health Care Services
Fairfax, United States Active
Researchers
- Principal investigator: Cooper, Lauren Beth — Inova Health Care Services
- Study coordinator: Cooper, Lauren Beth
Related research
Other NIH-funded projects on the same topics.
-
AI-supported heart failure diagnosis and management in Rwanda
Aiming to help people with suspected heart failure in Rwanda get faster, more accurate diagnoses and better care using AI-guided ultrasound and care protocols.
-
AI-assisted heart failure diagnosis in Rwanda using focused ultrasound
An NIH-funded project will test whether AI-enhanced, easy-to-use heart ultrasound can help non-experts diagnose and manage heart failure in Rwanda.
-
HF endotypes in heart failure using ethical multi-modal AI and molecular data
A patient-friendly project that uses advanced AI and multiple kinds of health data to identify distinct heart failure subtypes that could guide personalized care.
-
Triple gene therapy approach to heal the heart after a heart attack
A new therapy combines three genetic approaches delivered by a virus to help the heart heal after a heart attack.
-
Digital-first heart failure care delivery in Uganda
A targeted program in Uganda tests a digital care plan to help people with heart failure manage their symptoms at home.
-
Digital-first heart failure care delivery in Uganda
A study to test digital self-care tools to help people with heart failure in Uganda manage symptoms and stay healthier.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.