Comparing the effects of two diuretics on heart failure outcomes
The optimal loop diuretic: mechanistic insights from longitudinal changes in blood and urine proteins to explain efficacy and safety of torsemide vs furosemide after a heart failure hospitalization
This study is looking at how two common water pills, torsemide and furosemide, help people with heart failure after they leave the hospital, and it aims to find out if one works better or is safer than the other for different groups of patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Inova Health Care Services NIH-funded |
| Lab location | 1 site (Fairfax, UNITED STATES) |
| Project ID | NIH-10683741 on NIH RePORTER |
What this research studies
This research investigates how two commonly used diuretics, torsemide and furosemide, affect patients with heart failure after hospitalization. By collecting blood and urine samples from participants at the start of the study and again after 90 days, researchers will analyze the proteins present to understand how each medication works in the body. The goal is to determine if one diuretic is more effective or safer than the other, particularly across different patient groups defined by gender, race, and heart function. This study aims to provide insights that could improve treatment decisions for heart failure patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients who have been hospitalized for heart failure and are prescribed diuretics.
Not a fit: Patients who are not hospitalized for heart failure or those who do not require diuretic therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more personalized and effective treatment options for heart failure patients.
How similar studies have performed: Previous research has shown varying outcomes with different diuretics in heart failure, but this specific mechanistic approach is novel.
Where this research is happening
Fairfax, UNITED STATES
- Inova Health Care Services — Fairfax, United States (Active)
Researchers
- Principal investigator: Cooper, Lauren Beth — Inova Health Care Services
- Study coordinator: Cooper, Lauren Beth
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.