Comparing the effects of fish oil components on blood clotting
Official title: Differential thrombogenesis effects of EPA and DHA mediated by HDL
Funded at Miriam Hospital · NIH-10828430 · Data updated 2026-11-12
This study is looking at how two types of omega-3 fatty acids, EPA and DHA, can help improve heart health and blood clotting in people with a specific cholesterol issue, and it will compare how each one affects the body to see which might be more beneficial.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Miriam Hospital NIH-funded |
| Lab location | 1 site (Providence, United States) |
| Project start | April 1, 2024 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $526,228 |
| NIH project number | 5R01HL159204-03 |
| Project ID | NIH-10828430 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with atherogenic dyslipidemia, a condition characterized by abnormal lipid levels that increase cardiovascular risk.
✕Less likely to help
Patients without atherogenic dyslipidemia or those who do not consume omega-3 fatty acids may not benefit from this research.
What this research studies
This research investigates how two specific omega-3 fatty acids, EPA and DHA, affect blood clotting and cardiovascular health in patients with atherogenic dyslipidemia. By conducting a clinical study, researchers will compare the biological effects of these fatty acids to understand their roles in modifying high-density lipoprotein (HDL) function and their potential antithrombotic properties. Patients will receive either EPA or DHA to observe differences in their impact on thrombogenesis, which is the process of blood clot formation. The study aims to clarify why previous trials have shown inconsistent results regarding the cardiovascular benefits of omega-3 fatty acids.
Why it matters
Potential benefit: If successful, this research could lead to more effective dietary recommendations or treatments for reducing cardiovascular risk in patients with specific lipid disorders.
How similar studies have gone: While there have been studies on omega-3 fatty acids, this specific head-to-head comparison of EPA and DHA's effects on thrombogenesis is novel and has not been extensively tested.
Where this research is happening
-
Miriam Hospital
Providence, United States Active
Researchers
- Principal investigator: Song, Wenliang — Miriam Hospital
- Study coordinator: Song, Wenliang
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.