Comparing the effectiveness of weight loss medications for heart and metabolic health
Official title: Comparative effectiveness of anti-obesity medications for cardiometabolic health outcomes and health services use
Funded at Harvard Pilgrim Health Care, INC. · NIH-10997392 · Data updated 2026-11-12
This study looks at how various weight loss medications can help improve heart and overall health in adults with obesity, so doctors can better choose the right options for their patients trying to manage their weight and related health concerns.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Harvard Pilgrim Health Care, INC. NIH-funded |
| Lab location | 1 site (Canton, UNITED STATES) |
| Project start | December 15, 2023 |
| Project end | November 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $636,686 |
| NIH project number | 5R01HL171293-02 |
| Project ID | NIH-10997392 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults aged 21 and older who are struggling with obesity and related conditions such as hypertension or diabetes.
✕Less likely to help
Patients who are not affected by obesity or do not have related health complications may not benefit from this research.
What this research studies
This research investigates how different anti-obesity medications (AOMs) affect heart and metabolic health outcomes in adults with obesity. By analyzing a large dataset of insurance claims, the study aims to determine which medications are most effective and safe for long-term weight management. The findings could help guide doctors in prescribing AOMs and improve treatment options for patients struggling with obesity and related health issues. The research will also explore the impact of these medications on healthcare utilization.
Why it matters
Potential benefit: If successful, this research could provide patients with more effective and safer options for managing obesity and its related health complications.
How similar studies have gone: Previous research has shown promising results with anti-obesity medications, but this study aims to provide the first comprehensive comparative effectiveness analysis, making it a novel approach.
Where this research is happening
-
Harvard Pilgrim Health Care, INC.
Canton, United States Active
Researchers
- Principal investigator: Toh, Darren — Harvard Pilgrim Health Care, INC.
- Study coordinator: Toh, Darren
Related research
Other NIH-funded projects on the same topics.
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Training new researchers to help reduce obesity and improve heart health
This study is all about finding new ways to help people manage their weight and improve their heart and metabolic health, focusing on what really works for keeping weight off and making healthy lifestyle changes.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.