Comparing the effectiveness of different biologic treatments for asthma
Official title: Emulating hypothetical target trials to establish the comparative effectiveness of biologics in asthma
Funded at Brigham and Women's Hospital · NIH-11128166 · Data updated 2026-11-12
This study looks at how well different biologic treatments help people with severe asthma who haven't found relief with regular medications, so we can figure out which options work best for them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | June 1, 2025 |
| Project end | March 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $834,840 |
| NIH project number | 1R01HL173055-01A1 |
| Project ID | NIH-11128166 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with severe asthma who are not adequately controlled on conventional therapies and are eligible for multiple biologic treatments.
✕Less likely to help
Patients with mild or well-controlled asthma may not benefit from this research as it focuses on severe cases requiring advanced treatment options.
What this research studies
This research investigates how well various biologic treatments work for patients with severe asthma who do not respond to standard therapies. By analyzing real-world data, the study aims to determine which biologic is most effective for patients who qualify for multiple treatment options. The approach focuses on understanding the comparative effectiveness of these treatments to provide better guidance for clinicians and patients. The goal is to improve treatment outcomes and optimize the use of these expensive therapies.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatment choices for patients with severe asthma, potentially reducing morbidity and improving quality of life.
How similar studies have gone: Previous research has shown promise in using real-world data to compare treatment effectiveness, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Brigham and Women's Hospital
Boston, United States Active
Researchers
- Principal investigator: Akenroye, Ayobami T — Brigham and Women's Hospital
- Study coordinator: Akenroye, Ayobami T
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.