Comparing standard and high doses of buprenorphine for opioid addiction treatment.

CCC TO 11 - CTN-0145: STANDARD VERSUS HIGH DOSE ED-INITIATED BUPRENORPHINE INDUCTION. POP: 8/28/23 - 8/27/27.

NIH-funded research The Emmes Company, LLC · NIH-11219441

This study is looking at whether a regular or higher dose of buprenorphine works better for people starting treatment for opioid addiction, and it's designed for anyone who wants help with their addiction.

Quick facts

Grant typeNIH-funded research
Study typeNIH-funded research
Funding institutionThe Emmes Company, LLC NIH-funded
Lab location1 site (Rockville, United States)
Project IDNIH-11219441 on NIH RePORTER

What this research studies

This research investigates the effectiveness of standard versus high doses of buprenorphine in initiating treatment for individuals struggling with opioid addiction. Participants will receive either dosage to determine which is more effective in helping them manage their addiction. The study is part of the NIH's HEAL initiative, which aims to find rapid and effective solutions to the opioid crisis. Patients will be monitored throughout the treatment process to assess outcomes and improve future treatment strategies.

Who could benefit from this research

Good fit: Ideal candidates for this research are individuals diagnosed with opioid use disorder who are seeking treatment.

Not a fit: Patients who are not struggling with opioid addiction or who are not seeking treatment may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could lead to more effective treatment options for individuals with opioid addiction, potentially improving recovery rates.

How similar studies have performed: Previous research has shown promising results in using buprenorphine for opioid addiction treatment, indicating that this approach has potential for success.

Where this research is happening

Rockville, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-10 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.