Comparing risk factors for men with and without prostate cancer
Official title: A Comparative Study of Risk Factors for Men with and without Prostate Cancer at the VA Medical Center in Durham
Funded at Cedars-Sinai Medical Center · NIH-11064573 · Data updated 2026-11-12
This study is looking at how certain treatments for prostate cancer, like hormone therapy, affect men's health and whether a special diet can help improve their well-being during treatment.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cedars-Sinai Medical Center NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $119,705 |
| NIH project number | 3R01CA280081-02S1 |
| Project ID | NIH-11064573 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include men diagnosed with prostate cancer, particularly those undergoing androgen deprivation therapy.
✕Less likely to help
Patients with prostate cancer who are not undergoing treatment or those with other unrelated health conditions may not benefit from this research.
What this research studies
This research investigates the differences in risk factors between men diagnosed with prostate cancer and those without it, focusing on the effects of androgen deprivation therapy (ADT) and its associated metabolic changes. The study utilizes a fasting-mimicking diet (FMD) to assess its impact on insulin, glucose, and other biological markers in prostate cancer patients. By analyzing these factors, the research aims to identify potential strategies to mitigate treatment-related toxicities and improve overall health outcomes for men undergoing prostate cancer treatment.
Why it matters
Potential benefit: If successful, this research could lead to improved management of prostate cancer treatment side effects and better health outcomes for patients.
How similar studies have gone: Previous studies have shown promising results with fasting-mimicking diets in improving metabolic health and delaying tumor progression in animal models, suggesting potential for success in human applications.
Where this research is happening
-
Cedars-Sinai Medical Center
Los Angeles, United States Active
Researchers
- Principal investigator: Freedland, Stephen Jay — Cedars-Sinai Medical Center
- Study coordinator: Freedland, Stephen Jay
Related research
Other NIH-funded projects on the same topics.
-
IOP and CSF Pressure in Glaucoma Risk
This grant studies how eye pressure and cerebrospinal fluid pressure together influence glaucoma risk and vision loss.
-
ALS risk factors in a long-term ALS study
A long-term ALS study is looking at which factors may influence disease risk and progression in people living with ALS.
-
Understanding how work exposures and genes influence ALS risk
A study is building a long-term group of people at higher risk for ALS to see how their jobs, exposures at work, and genes together affect if and when the disease might develop.
-
Cardiovascular risk planning and reduction for men with prostate cancer
A program to better predict and reduce heart disease risk in men treated for prostate cancer, especially older patients.
-
Effects of ADT on motivation and emotion in prostate cancer patients
This project looks at how androgen deprivation therapy may affect motivation and mood over time in men with prostate cancer.
-
Causal Protein Markers to Understand and Predict Prostate Cancer Risk in Africans and Europeans
A cancer research project looking at proteins linked to prostate cancer to better understand why it happens and how risk differs between African and European populations.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.