Comparing proteins in different types of Alzheimer's disease
Official title: A Proteomic Comparison of Sporadic Early-Onset, Late-Onset, and Autosomal Dominant Alzheimer's Disease
Funded at Emory University · NIH-10985491 · Data updated 2026-11-12
This study is looking at how brain proteins change in different types of Alzheimer's disease, especially for those with early-onset Alzheimer's, to help us understand their unique challenges and improve care for them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | September 30, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $2,840,883 |
| NIH project number | 1R01AG089497-01 |
| Project ID | NIH-10985491 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with sporadic early-onset Alzheimer's disease, particularly those under the age of 65.
✕Less likely to help
Patients with late-onset Alzheimer's disease or those without a diagnosis of Alzheimer's may not benefit from this research.
What this research studies
This research investigates the differences in protein changes among various forms of Alzheimer's disease, specifically focusing on sporadic early-onset Alzheimer's disease (sEOAD), late-onset Alzheimer's disease (LOAD), and autosomal dominant Alzheimer's disease (ADAD). By analyzing brain proteins, the study aims to uncover how these forms of Alzheimer's may differ in their biological pathways and symptoms. Patients with sEOAD often experience unique cognitive challenges and a more rapid progression of the disease, making this research crucial for understanding their specific needs. The findings could lead to better diagnostic tools and treatment strategies tailored to these different forms of Alzheimer's.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients with early-onset Alzheimer's disease.
How similar studies have gone: Previous research on late-onset Alzheimer's disease has shown promising results using similar proteomic approaches, indicating potential for success in this area as well.
Where this research is happening
-
Emory University
Atlanta, United States Active
Researchers
- Principal investigator: Johnson, Erik C.b. — Emory University
- Study coordinator: Johnson, Erik C.b.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.