Comparing procedures for treating narrowed carotid arteries
Official title: Comparative-Effectiveness of Procedures for Carotid Revascularization
Funded at Dartmouth-Hitchcock Clinic · NIH-11089373 · Data updated 2026-11-12
This study is looking at three different ways to treat narrowed carotid arteries to help prevent strokes, so if you're at risk for a stroke, it will help find out which method works best and is safest for you.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Dartmouth-Hitchcock Clinic NIH-funded |
| Lab location | 1 site (Lebanon, United States) |
| Project start | June 1, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $146,808 |
| NIH project number | 5K08HL165087-03 |
| Project ID | NIH-11089373 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with carotid artery stenosis who are at risk for ischemic stroke.
✕Less likely to help
Patients who do not have carotid artery stenosis or those who are not at risk for stroke may not benefit from this research.
What this research studies
This research investigates the effectiveness and safety of three procedures for carotid revascularization: surgical carotid endarterectomy (CEA), percutaneous transfemoral carotid artery stenting (TF-CAS), and the newer transcarotid artery revascularization (TCAR). While CEA and TF-CAS have been extensively studied, TCAR's efficacy is less understood due to limited research. The study aims to provide clearer insights into these procedures to help manage patients at risk of ischemic stroke due to carotid artery stenosis. Patients will be monitored and assessed to determine which procedure offers the best outcomes.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options for patients with carotid artery stenosis, potentially reducing their risk of stroke.
How similar studies have gone: While CEA and TF-CAS have shown success in previous studies, TCAR is relatively new and has not been rigorously tested in large-scale trials.
Where this research is happening
-
Dartmouth-Hitchcock Clinic
Lebanon, United States Active
Researchers
- Principal investigator: Columbo, Jesse a — Dartmouth-Hitchcock Clinic
- Study coordinator: Columbo, Jesse a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.