Comparing natural COVID-19 infection and vaccine-induced immunity in pregnant women and their infants
Official title: SARS-CoV-2 in Pregnancy: Comparison of Natural Infection and Hybrid Immunity in Mother-Infant Pairs
Funded at University of California Los Angeles · NIH-10881968 · Data updated 2026-11-12
This study is looking at how getting COVID-19 and being vaccinated during pregnancy affects both moms and their babies, especially how different types of immunity can help protect newborns.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | July 5, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $203,580 |
| NIH project number | 5K23AI177952-02 |
| Project ID | NIH-10881968 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation include pregnant women who have experienced either natural SARS-CoV-2 infection or vaccination against COVID-19.
✕Less likely to help
Patients who are not pregnant or those who have not been exposed to SARS-CoV-2 or vaccinated may not benefit from this research.
What this research studies
This research investigates the effects of SARS-CoV-2 infection and vaccination during pregnancy on both mothers and their infants. It aims to understand how hybrid immunity, which combines natural infection and vaccination, influences immune responses in pregnant women compared to those who only experience natural infection. By studying mother-infant pairs, the research will explore the long-term immunological impacts of these different types of immunity, particularly focusing on the transfer of protective antibodies to newborns. This study leverages data from an existing cohort of mothers and infants affected by COVID-19 during pregnancy.
Why it matters
Potential benefit: If successful, this research could enhance understanding of how to protect pregnant women and their infants from severe COVID-19 outcomes.
How similar studies have gone: Previous research has shown promising results in understanding immunity in pregnant populations, but this specific comparison of hybrid immunity is relatively novel.
Where this research is happening
-
University of California Los Angeles
Los Angeles, United States Active
Researchers
- Principal investigator: Cambou, Mary Catherine — University of California Los Angeles
- Study coordinator: Cambou, Mary Catherine
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.