Comparing methadone and buprenorphine for treating opioid use disorder
Official title: OFFICE-BASED METHADONE VS BUPRENORPHINE TO ADDRESS RETENTION IN MEDICATION FOR OPIOID USE DISORDER (MOUD)-A PRAGMATIC HYBRID EFFECTIVENESS/IMPLEMENTAT
Funded at The Emmes Company, LLC · NIH-10720985 · Data updated 2026-11-12
This study is looking at how well methadone and buprenorphine help people stick with their treatment for opioid addiction, and it’s designed for anyone who wants to understand which medication might work better for them in real-life situations.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | The Emmes Company, LLC NIH-funded |
| Lab location | 1 site (Rockville, United States) |
| Project start | September 28, 2022 |
| Project end | August 4, 2025 |
| Funding year | 2022 |
| Award (this year) | $1,026,853 |
| NIH project number | 75N95022D00017-0-759502200003-1 |
| Project ID | NIH-10720985 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with opioid use disorder who are seeking medication-assisted treatment.
✕Less likely to help
Patients who are not struggling with opioid use disorder or those who are not seeking treatment may not benefit from this research.
What this research studies
This research investigates the effectiveness of methadone versus buprenorphine in retaining patients in medication for opioid use disorder. It employs a pragmatic hybrid effectiveness/implementation approach, meaning it will assess not only how well these medications work in real-world settings but also how they can be effectively implemented in clinical practice. Patients may be monitored for their retention in treatment and overall health outcomes as part of this research. The study aims to provide insights that could help improve treatment strategies for individuals struggling with opioid addiction.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options and retention rates for patients with opioid use disorder.
How similar studies have gone: Previous research has shown promising results in comparing different medication-assisted treatments for opioid use disorder, suggesting that this approach could yield valuable insights.
Where this research is happening
-
The Emmes Company, LLC
Rockville, United States Active
Researchers
- Principal investigator: Mccormack, Jennifer — The Emmes Company, LLC
- Study coordinator: Mccormack, Jennifer
Related research
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.