Comparing ketamine and midazolam for treating suicidal thoughts in adolescents
Double-Blind Randomized Controlled Trial of Acute-Course of Ketamine Versus Midazolam for Recurrence of Suicidality in Adolescents
['FUNDING_R01'] · UT SOUTHWESTERN MEDICAL CENTER · NIH-10689903
This study is looking at how well ketamine works compared to midazolam in helping young people who are feeling suicidal, by giving them treatments over two weeks and checking how they feel afterward.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UT SOUTHWESTERN MEDICAL CENTER (nih funded) |
| Locations | 1 site (DALLAS, UNITED STATES) |
| Trial ID | NIH-10689903 on ClinicalTrials.gov |
What this research studies
This research investigates the effectiveness of ketamine compared to midazolam in reducing suicidal thoughts and behaviors in adolescents. Participants will receive either intravenous ketamine or midazolam in an intensive outpatient program designed for youths who have recently experienced suicidal events. The study will involve four infusions over two weeks, with follow-up assessments to evaluate the impact on repeat suicide attempts, implicit suicidal thoughts, and overall depression levels. The goal is to identify a rapid-acting treatment option for adolescents at risk of suicide.
Who could benefit from this research
Good fit: Ideal candidates for this research are adolescents aged 15-24 who have recently exhibited suicidal behaviors.
Not a fit: Patients who are not experiencing suicidal thoughts or behaviors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide a new, effective treatment option for adolescents experiencing suicidal thoughts, potentially reducing the risk of repeat suicide attempts.
How similar studies have performed: Previous studies have shown promising results for ketamine in treating suicidality in adults, but this specific approach in adolescents is novel.
Where this research is happening
DALLAS, UNITED STATES
- UT SOUTHWESTERN MEDICAL CENTER — DALLAS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: TRIVEDI, MADHUKAR H. — UT SOUTHWESTERN MEDICAL CENTER
- Study coordinator: TRIVEDI, MADHUKAR H.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.