Comparing human sensory neurons with those made from stem cells
Genetic and physiological comparison of native human sensory neurons and induced pluripotent stem cells differentiated to sensory neurons
This study is looking at how natural human nerve cells and lab-made nerve cells respond to pain and injury, with the hope of finding new ways to help manage pain better for patients like you.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Cincinnati NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project ID | NIH-10573702 on NIH RePORTER |
What this research studies
This research investigates the differences between native human sensory neurons and those created from induced pluripotent stem cells. By analyzing gene expression and physiological characteristics, the study aims to understand how these two types of neurons respond to pain and injury. The goal is to identify any critical differences that could affect the development of new pain treatments. Patients may benefit from insights that could lead to more effective pain management strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults experiencing chronic pain or those interested in pain management therapies.
Not a fit: Patients with acute pain conditions or those not experiencing chronic pain may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for chronic pain conditions.
How similar studies have performed: While there has been significant research on sensory neurons, this specific comparison between native and stem cell-derived neurons is relatively novel.
Where this research is happening
Cincinnati, United States
- University of Cincinnati — Cincinnati, United States (Active)
Researchers
- Principal investigator: Berta, Temugin — University of Cincinnati
- Study coordinator: Berta, Temugin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.