Comparing how different species use cholinergic signals in the brain
Official title: Cross-Species comparison of cholinergic neuromodulation in mice and primates
Funded at Baylor College of Medicine · NIH-10888717 · Data updated 2026-11-12
This study looks at how the brain uses certain signals to help with its functions by comparing mice and primates, and the goal is to find new ways to help people with brain conditions that affect these signals.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | June 3, 2025 |
| Project end | May 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $370,462 |
| NIH project number | 1R34NS137454-01 |
| Project ID | NIH-10888717 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit would include individuals with neurological conditions that may involve cholinergic system dysfunction.
✕Less likely to help
Patients with conditions unrelated to cholinergic signaling may not receive any benefit from this research.
What this research studies
This research investigates the mechanisms of cholinergic neuromodulation by comparing the brain functions of mice and primates. By examining how these species process cholinergic signals, the study aims to uncover fundamental insights into brain function that could inform future treatments for neurological conditions. The approach involves advanced neurobiological techniques to analyze brain activity and signaling pathways across species. Patients may benefit from the findings as they could lead to new therapeutic strategies for conditions related to cholinergic dysfunction.
Why it matters
Potential benefit: If successful, this research could provide new insights into treating neurological disorders linked to cholinergic signaling.
How similar studies have gone: While this specific approach is novel, similar comparative studies in neuromodulation have shown promising results in understanding brain function.
Where this research is happening
-
Baylor College of Medicine
Houston, United States Active
Researchers
- Principal investigator: Reimer, Jacob — Baylor College of Medicine
- Study coordinator: Reimer, Jacob
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.