Comparing high and standard dose flu vaccines for organ transplant patients
Official title: Comparison of High vs. Standard Dose Influenza Vaccines in Adult Solid Organ Transplant Recipients
Funded at Vanderbilt University Medical Center · NIH-10875512 · Data updated 2026-11-12
This study is looking at how different amounts of the flu vaccine work for adults who have had organ transplants, especially those who had their transplant within the last year, to find out which dose helps them build a stronger defense against the flu.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project start | September 1, 2020 |
| Project end | June 30, 2025 |
| Funding year | 2024 |
| Award (this year) | $817,174 |
| NIH project number | 5U01AI152967-05 |
| Project ID | NIH-10875512 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adult solid organ transplant recipients who are between 1 to 11 months post-transplant.
✕Less likely to help
Patients who are not solid organ transplant recipients or those who are more than 12 months post-transplant may not benefit from this research.
What this research studies
This research investigates how different doses of the influenza vaccine affect adult patients who have received solid organ transplants. It focuses on comparing high-dose and standard-dose vaccines to determine which provides better immune responses, especially in patients who are within 12 months of their transplant. The study aims to identify the best vaccination strategy to protect these vulnerable individuals from influenza, a significant health risk for them. By analyzing immune responses, the research seeks to improve vaccination protocols for this population.
Why it matters
Potential benefit: If successful, this research could lead to more effective flu vaccination strategies for organ transplant recipients, enhancing their protection against influenza.
How similar studies have gone: Previous studies have shown promising results with high-dose influenza vaccines in similar populations, indicating potential for success in this approach.
Where this research is happening
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Vanderbilt University Medical Center
Nashville, United States Active
Researchers
- Principal investigator: Halasa, Natasha Bassam — Vanderbilt University Medical Center
- Study coordinator: Halasa, Natasha Bassam
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.