Comparing high and standard dose flu vaccines for children who received organ transplants
Official title: Comparison of High vs. Standard Dose Influenza Vaccine in Pediatric Solid Organ Transplant Recipients
Funded at Vanderbilt University Medical Center · NIH-11077271 · Data updated 2026-11-12
This study is looking at how well kids who have had organ transplants respond to different amounts of the flu vaccine, to find out the best way to help keep them safe from the flu.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project start | June 9, 2023 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $1,631,325 |
| NIH project number | 5U01AI167799-03 |
| Project ID | NIH-11077271 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are pediatric patients under 11 years old who have received solid organ transplants.
✕Less likely to help
Patients who are not solid organ transplant recipients or those over 11 years old may not benefit from this research.
What this research studies
This research investigates how well pediatric solid organ transplant recipients respond to different doses of the influenza vaccine. It compares the effectiveness of a high-dose vaccine versus a standard-dose vaccine, as well as the impact of administering two doses of the standard vaccine in the same flu season. The goal is to determine the best vaccination strategy to enhance immune responses in these vulnerable children, particularly those who are less than 24 months post-transplant. By analyzing immune responses and safety, the study aims to improve flu protection for these patients.
Why it matters
Potential benefit: If successful, this research could lead to more effective flu vaccination strategies for children who have undergone organ transplants, improving their health outcomes.
How similar studies have gone: Previous studies have shown promising results with high-dose vaccines in adult transplant recipients, but this specific approach in pediatric populations is novel.
Where this research is happening
-
Vanderbilt University Medical Center
Nashville, United States Active
Researchers
- Principal investigator: Halasa, Natasha Bassam — Vanderbilt University Medical Center
- Study coordinator: Halasa, Natasha Bassam
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.