Comparing frozen embryo transfers in natural versus programmed cycles
1/3 A randomized controlled trial of frozen embryo transfers performed in modified natural versus programmed cycles (NatPro)
['FUNDING_R01'] · JOHNS HOPKINS UNIVERSITY · NIH-10846307
This study is looking at whether using a natural cycle or a programmed cycle for frozen embryo transfers can help lower the chances of high blood pressure problems during pregnancy, like preeclampsia, for women going through IVF.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | JOHNS HOPKINS UNIVERSITY (nih funded) |
| Locations | 1 site (BALTIMORE, UNITED STATES) |
| Trial ID | NIH-10846307 on ClinicalTrials.gov |
What this research studies
This research investigates the effects of frozen embryo transfers (FET) performed in two different types of cycles: modified natural cycles with a corpus luteum and programmed cycles without it. The study aims to determine if performing FET in a natural cycle can reduce the risk of hypertensive disorders during pregnancy, such as preeclampsia, which can have serious consequences for both mothers and infants. Women undergoing in vitro fertilization (IVF) will be randomly assigned to one of the two cycle types to assess the outcomes. The research is crucial for improving the safety and effectiveness of assisted reproductive technologies.
Who could benefit from this research
Good fit: Ideal candidates for this research are women who are planning to undergo IVF with frozen embryo transfers.
Not a fit: Patients who are not undergoing IVF or those who are not using frozen embryos may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to safer pregnancy outcomes for women undergoing frozen embryo transfers.
How similar studies have performed: Other studies have indicated potential risks associated with frozen embryo transfers, but this specific approach comparing cycle types is novel and aims to provide definitive answers.
Where this research is happening
BALTIMORE, UNITED STATES
- JOHNS HOPKINS UNIVERSITY — BALTIMORE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BAKER, VALERIE LYNN — JOHNS HOPKINS UNIVERSITY
- Study coordinator: BAKER, VALERIE LYNN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.