Comparing frozen embryo transfer methods to improve pregnancy outcomes
1/3 A randomized controlled trial of frozen embryo transfers performed in modified natural versus programmed cycles (NatPro)
This study is looking at how two different ways of transferring frozen embryos might affect pregnancy health, especially the risk of high blood pressure issues like preeclampsia, to help find the safest option for moms and babies.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10684620 on NIH RePORTER |
What this research studies
This research investigates the effects of two different methods of frozen embryo transfer (FET) on pregnancy outcomes, specifically focusing on the risk of hypertensive disorders like preeclampsia. The study compares programmed cycles to modified natural cycles to determine which method may lead to safer pregnancies and better live birth rates. By analyzing maternal cardiovascular responses during pregnancy, the research aims to identify the optimal protocol for FET that minimizes risks for both mothers and infants. Patients participating in this research will contribute to understanding how these methods affect pregnancy health.
Who could benefit from this research
Good fit: Ideal candidates for this research are women undergoing assisted reproductive technology who are considering frozen embryo transfers.
Not a fit: Patients who are not undergoing frozen embryo transfers or those with contraindications to pregnancy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to safer frozen embryo transfer protocols, reducing the risk of complications like preeclampsia and improving live birth rates.
How similar studies have performed: Previous studies have indicated that different FET protocols can significantly impact pregnancy outcomes, suggesting that this research could build on established findings.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Baker, Valerie Lynn — Johns Hopkins University
- Study coordinator: Baker, Valerie Lynn
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.