Comparing frozen embryo transfer methods to improve pregnancy outcomes
3/3- A randomized controlled trial of frozen embryo transfers performed in modified natural versus programmed cycles (NatPro)
This study is looking at two ways to transfer frozen embryos to see which one helps women have healthier pregnancies with less risk of high blood pressure issues, like preeclampsia, and it's for patients who are using assisted reproductive technology.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-10682513 on NIH RePORTER |
What this research studies
This research investigates the effects of two different methods of frozen embryo transfer (FET) on pregnancy outcomes, specifically focusing on the risk of hypertensive disorders like preeclampsia. Patients undergoing assisted reproductive technology will be randomly assigned to receive either a programmed or a natural cycle FET. The study aims to determine which method is safer and more effective in achieving successful pregnancies while minimizing risks to both mothers and infants. By analyzing maternal cardiovascular responses during pregnancy, the research seeks to provide clearer guidelines for clinicians.
Who could benefit from this research
Good fit: Ideal candidates for this research are women undergoing assisted reproductive technology who are considering frozen embryo transfers.
Not a fit: Patients who are not undergoing frozen embryo transfers or those with contraindications to assisted reproductive technology may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to safer frozen embryo transfer protocols, reducing the risk of complications during pregnancy.
How similar studies have performed: Previous studies have indicated potential risks associated with different FET protocols, but this research aims to provide more definitive evidence on the safest approach.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Lathi, Ruth B — Stanford University
- Study coordinator: Lathi, Ruth B
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.