Comparing early and delayed umbilical cord clamping in newborns with congenital heart disease
Official title: 1/2 CORD-CHD: Clamp OR Delay among neonates with Congenital Heart Disease
Funded at Research Inst Nationwide Children's Hosp · NIH-11062509 · Data updated 2026-11-12
This study is looking at how two different ways of clamping the umbilical cord—either right after birth or a little later—affect newborns with congenital heart disease, to see which method helps these babies the most.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Research Inst Nationwide Children's Hosp NIH-funded |
| Lab location | 1 site (Columbus, United States) |
| Project start | April 1, 2023 |
| Project end | March 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $812,290 |
| NIH project number | 5UH3HL166794-03 |
| Project ID | NIH-11062509 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are newborns diagnosed with congenital heart disease who are undergoing delivery.
✕Less likely to help
Patients who are not newborns or those without congenital heart disease may not benefit from this research.
What this research studies
This research investigates the effects of two different umbilical cord clamping methods—early clamping and delayed clamping—on newborns diagnosed with congenital heart disease. The study aims to determine which method is more beneficial for these high-risk infants, as previous research has shown advantages of delayed clamping in healthy newborns. By conducting a randomized controlled trial, the researchers will assess outcomes such as blood transfer from the placenta and potential impacts on iron levels and neurodevelopment. This trial is particularly important because the unique physiological characteristics of infants with congenital heart disease may influence the effectiveness of these clamping methods.
Why it matters
Potential benefit: If successful, this research could lead to improved health outcomes for newborns with congenital heart disease by identifying the optimal cord clamping method.
How similar studies have gone: Previous studies have shown success with delayed cord clamping in healthy newborns, but this research is novel as it focuses specifically on infants with congenital heart disease.
Where this research is happening
-
Research Inst Nationwide Children's Hosp
Columbus, United States Active
Researchers
- Principal investigator: Backes, Carl — Research Inst Nationwide Children's Hosp
- Study coordinator: Backes, Carl
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.