Comparing blood thinners for patients with liver disease and irregular heartbeat
The Comparative Effectiveness and Safety of Oral Anticoagulants in Patients with Cirrhosis and Atrial Fibrillation
This study is looking at how well different blood thinners work and how safe they are for people who have both liver cirrhosis and atrial fibrillation, to help find the best treatment for those at risk of stroke.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11026362 on NIH RePORTER |
What this research studies
This research investigates the effectiveness and safety of different oral anticoagulants (blood thinners) in patients who have both cirrhosis and atrial fibrillation. It aims to understand why many patients with these conditions are not receiving anticoagulation therapy despite their high risk of stroke. The study will analyze various anticoagulant options, including warfarin and direct oral anticoagulants, to determine the best treatment approach for this vulnerable population. By focusing on real-world data, the research seeks to provide insights that could improve patient care and outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 21 years old who have been diagnosed with both cirrhosis and atrial fibrillation.
Not a fit: Patients without cirrhosis or atrial fibrillation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better treatment strategies that reduce the risk of stroke in patients with cirrhosis and atrial fibrillation.
How similar studies have performed: While there has been significant research on anticoagulants in the general population, this specific focus on patients with cirrhosis and atrial fibrillation is largely untested, making it a novel approach.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Simon, Tracey — Brigham and Women's Hospital
- Study coordinator: Simon, Tracey
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.