Comparing balanced fluids to normal saline for treating sepsis in children
PRagMatic Pediatric Trial of Balanced versus NOrmaL Saline FlUid in Sepsis (PRoMPT BOLUS)
This study is looking at how two different types of IV fluids can help kids with sepsis, a serious infection, to see which one works better for their recovery and kidney health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hosp of Philadelphia NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10897330 on NIH RePORTER |
What this research studies
This research investigates the effectiveness of two types of intravenous fluids—balanced fluids and normal saline—in treating children with sepsis, a life-threatening condition caused by infections. The study aims to determine which fluid type provides better outcomes in terms of kidney function and overall survival. By enrolling pediatric patients experiencing septic shock, the research will gather data on how these fluids impact recovery and health. The findings could help establish best practices for fluid resuscitation in emergency settings.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 0-11 years who are diagnosed with sepsis or septic shock and require fluid resuscitation.
Not a fit: Patients who are not experiencing sepsis or are outside the pediatric age range may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment protocols for children with sepsis, potentially reducing complications and mortality rates.
How similar studies have performed: Previous adult studies have shown that balanced fluids can reduce adverse kidney events and mortality, suggesting potential benefits for pediatric patients as well.
Where this research is happening
Philadelphia, United States
- Children's Hosp of Philadelphia — Philadelphia, United States (Active)
Researchers
- Principal investigator: Balamuth, Frances B — Children's Hosp of Philadelphia
- Study coordinator: Balamuth, Frances B
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.